Synergistic Effects of Galantamine and Memantine in Attenuating Scopolamine-Induced Amnesia in Mice

Synergistic Effects of Galantamine and Memantine in Attenuating Scopolamine-Induced Amnesia in Mice

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We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in lock shock and barrel art the scopolamine-induced amnesia model in mice.We evaluated the effects of the two drugs, either alone or in combination, using the spontaneous alternation and object recognition tasks.In both tests, combination of low doses of galantamine (0.1 mg/kg, moondrop quarks s.c.

) and memantine (0.5 mg/kg, i.p.), which were sub-active per se, rescued the memory impairment induced by scopolamine (1 mg/kg, i.p.

).The results suggest that combinations of galantamine and memantine might provide a more effective treatment of memory impairments in cognitive disorders than either drug used alone.Keywords:: neurodegenerative disease, multi-target, memory impairment.